Alina Chan
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Yujia Alina Chan is a Canadian
molecular biologist Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...
specializing in
gene therapy Gene therapy is Health technology, medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. The first attempt at modifying human DNA ...
and cell engineering at the Broad Institute of MIT and Harvard, where she is a postdoctoral fellow. During the
COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December ...
, she became known for supporting the hypothesis that the
SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional nam ...
virus escaped from a lab, contrary to the prevailing consensus at the time regarding the origins of the virus.


Biography

Chan was born in
Vancouver, British Columbia Vancouver is a major city in Western Canada, located in the Lower Mainland region of British Columbia. As the List of cities in British Columbia, most populous city in the province, the 2021 Canadian census recorded 662,248 people in the cit ...
, to
Singaporean Singaporeans are the citizens and nationals of the sovereign island city-state of Singapore. Singapore is home to a people of a variety of ethno-racial-religious origins, with the city-state itself being a multi-racial, multi-cultural, m ...
parents. Her family returned to Singapore shortly after, where she grew up. She returned to Canada after high school to study
biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...
and
molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...
at the
University of British Columbia The University of British Columbia (UBC) is a Public university, public research university with campuses near University of British Columbia Vancouver, Vancouver and University of British Columbia Okanagan, Kelowna, in British Columbia, Canada ...
, where she earned a PhD. She then joined Harvard University as a postdoctoral scholar, later joining the Stanley Center for Psychiatric Research at the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institu ...
.


COVID-19 origins

Chan became known during the
COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December ...
for co-authoring a
preprint In academic publishing, a preprint is a version of a scholarly or scientific paper that precedes formal peer review and publication in a peer-reviewed scholarly or scientific journal. The preprint may be available, often as a non-typeset versi ...
according to which the SARS-CoV-2 virus was "pre-adapted" to humans and suggesting COVID-19 could have escaped from a laboratory. The preprint has not been accepted for publication by a
scientific journal In academic publishing, a scientific journal is a periodical publication designed to further the progress of science by disseminating new research findings to the scientific community. These journals serve as a platform for researchers, schola ...
, but received a significant reception in the popular press. The reaction of virologists and other specialists to Chan's hypothesis has been largely, but not exclusively, negative. The ''New York Times'' noted in October 2021 that Chan's view has been "widely disputed by other scientists", but some have commended her willingness to advance alternative hypotheses in the face of controversy. Jonathan Eisen of UC Davis praised Chan for raising the lab-origin discussion, but said her views remain conjecture, as not enough
disease outbreak In epidemiology, an outbreak is a sudden increase in occurrences of a disease when cases are in excess of normal expectancy for the location or season. It may affect a small and localized group or impact upon thousands of people across an entire ...
s have been traced in enough molecular detail to know what is normal, noting also that the virus continues to change and adapt. Sixteen months after Chan's preprint was shared online, a scientific review article published in '' Cell'' described the pre-adaptation theory as "without validity." Chan detailed her views on
Twitter Twitter, officially known as X since 2023, is an American microblogging and social networking service. It is one of the world's largest social media platforms and one of the most-visited websites. Users can share short text messages, image ...
and wrote opinion pieces on the subject with science journalist
Matt Ridley Matthew White Ridley, 5th Viscount Ridley (born 7 February 1958), is a British science writer, journalist and businessman. He is known for his writings on science, the environment, and economics, and has been a regular contributor to ''The Tim ...
in the ''
Wall Street Journal ''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...
'' and in ''
The Daily Telegraph ''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a British daily broadsheet conservative newspaper published in London by Telegraph Media Group and distributed in the United Kingdom and internationally. It was found ...
''. Chan later signed open letters together with other scientists published in the ''
Wall Street Journal ''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...
'' and ''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'', calling for full and unrestricted international forensic investigations into all possible origins of the virus. She was one of 18 scientists who signed a letter in ''
Science Magazine ''Science'' is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscrib ...
'' calling again for a credible investigation into the origins of the virus. The letter called for a "proper investigation" into "both natural and laboratory spillovers" and was widely covered in the press and brought the debate on the possible lab origins of the virus into the mainstream. Chan and Ridley authored a book entitled '' Viral: The Search for the Origin of COVID-19'', published by HarperCollins in November 2021. In September 2021, Chan participated in a debate on COVID-19 origins organized by ''
Science magazine ''Science'' is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscrib ...
'', which included scientists Linfa Wang, Michael Worobey, and Jesse Bloom. She detailed her position further in the ''New York Times'' in June 2024. Critiques of the NYT piece were posted by
David Gorski David Henry Gorski is an American surgical oncologist and professor of surgery at Wayne State University School of Medicine. He specializes in breast cancer surgery at the Karmanos Cancer Institute. Gorski is an outspoken skeptic and critic ...
on his blog ''
Science-Based Medicine ''Science-Based Medicine'' is a website and blog with articles covering issues in science and medicine, especially medical scams and practices. Founded in 2008, it is owned and operated by the New England Skeptical Society, and run by Steve ...
'', and by 41 scientists in the '' Journal of Virology''.


References


External links

* * {{DEFAULTSORT:Chan, Alina 21st-century Canadian biologists 21st-century Canadian women scientists Canadian molecular biologists Canadian people of Chinese descent Canadian people of Singaporean descent Canadian women biologists Living people Scientists from Vancouver University of British Columbia alumni Women molecular biologists Year of birth missing (living people)