Hermann Adolf Alexander Schmidt ( – ) was a

Baltic German Baltic Germans ( or , later ) are Germans, ethnic German inhabitants of the eastern shores of the Baltic Sea, in what today are Estonia and Latvia. Since Flight and expulsion of Germans (1944–1950), their resettlement in 1945 after the end ...

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...

from what was then the

Governorate of Livonia The Governorate of Livonia, also known as the Livonia Governorate, was a province (''guberniya'') and one of the Baltic governorates of the Russian Empire, Baltic Governorate-General until 1876. Governorate of Livonia bordered Governorate of E ...

in the

Russian Empire The Russian Empire was an empire that spanned most of northern Eurasia from its establishment in November 1721 until the proclamation of the Russian Republic in September 1917. At its height in the late 19th century, it covered about , roughl ...

. He was born on the island of Moon, which is today known by its Estonian name

Muhu Muhu (also called Muhumaa in Estonian) is an island in the West Estonian archipelago of the Baltic Sea. With an area of , it is the third largest island belonging to Estonia, after Saaremaa and Hiiumaa. Together with neighbouring smaller i ...

, in present-day

Estonia Estonia, officially the Republic of Estonia, is a country in Northern Europe. It is bordered to the north by the Gulf of Finland across from Finland, to the west by the Baltic Sea across from Sweden, to the south by Latvia, and to the east by Ru ...

. In 1858, he received his medical doctorate from the University of Dorpat, and later was an assistant to

Felix Hoppe-Seyler Ernst Felix Immanuel Hoppe-Seyler (''né'' Felix Hoppe; 26 December 1825 – 10 August 1895) was a German physiologist and chemist, and the principal founder of the disciplines of biochemistry and molecular biology. He had discovered Yeast nuclei ...

(1825-1895) in

Berlin Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population withi ...

, and to Carl Ludwig (1816-1895) in

Leipzig Leipzig (, ; ; Upper Saxon: ; ) is the most populous city in the States of Germany, German state of Saxony. The city has a population of 628,718 inhabitants as of 2023. It is the List of cities in Germany by population, eighth-largest city in Ge ...

. In 1869 he succeeded Friedrich Bidder (1810-1894) as professor of physiology at Dorpat, where he remained for the rest of his life. From 1885 to 1889 he served as university rector. Schmidt is remembered for his research involving the process of

blood coagulation Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulatio ...

by demonstrating that the transformation of

fibrinogen Fibrinogen (coagulation factor I) is a glycoprotein protein complex, complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted Enzyme, enzymatically by thrombin to fibrin ...

into

fibrin Fibrin (also called Factor Ia) is a fibrous protein, fibrous, non-globular protein involved in the Coagulation, clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerization, polymerize. ...

was the result of an enzymatic process. He named the hypothetical enzyme "

thrombin Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (, fibrose, thrombase, throm ...

", and he called its precursor "

prothrombin Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (, fibrose, thrombase, throm ...

". Schmidt is credited for providing a foundation for the creation of anti-coagulation systems and towards the development of

blood transfusion Blood transfusion is the process of transferring blood products into a person's Circulatory system, circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used ...

Selected works

* ''Weiteres über den Faserstoff und die Ursachen seiner Gerinnung'', 1862 – More information involving "faserstoff" and the causes of its coagulation. * ''Ueber Ozon im Blut'', 1862. (habilitation thesis for

privat-docent ''Privatdozent'' (for men) or ''Privatdozentin'' (for women), abbreviated PD, P.D. or Priv.-Doz., is an academic title conferred at some European universities, especially in German-speaking countries, to someone who holds certain formal qualifi ...

). 1862 – On

ozone Ozone () (or trioxygen) is an Inorganic compound, inorganic molecule with the chemical formula . It is a pale blue gas with a distinctively pungent smell. It is an allotrope of oxygen that is much less stable than the diatomic allotrope , break ...

in the blood. * ''Beiträge zur Kenntniss der Milch'', 1874 – Contributions to the understanding of milk. * ''Die Lehre von den fermentativen Gerinnungserscheinungen in den eiweissartigen thierischen Körperflüssigkeiten'', 1876. The doctrine of the fermentative coagulation phenomena in albuminous animal body fluids. * ''Zur Blutlehre''. Leipzig, F. C. W. Vogel, 1892 – Lessons on blood.Bibliography of Schmidt
@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograp ...

References

External links

Hemophilia Federation
The Coagulation Process

1831 births 1894 deaths People from Muhu Parish People from Kreis Ösel Baltic-German people from the Russian Empire Physiologists from the Russian Empire Rectors of universities in the Russian Empire Academic staff of the University of Tartu Rectors of the University of Tartu {{Germany-med-bio-stub