Aldosterone-to-renin ratio (ARR) is the mass concentration of

aldosterone Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays ...

divided by the

plasma renin activity Plasma renin activity (PRA), also known as the renin (active) assay or random plasma renin, is a measure of the activity of the plasma enzyme renin, which plays a major role in the body's regulation of blood pressure, thirst, and urine output. Me ...

or by serum renin concentration in blood. The aldosterone/renin ratio is recommended as screening tool for primary hyperaldosteronism.
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Tests

Interpretation

The cutoff (reference value), cutoff normal individuals from those with primary hyperaldosteronism is significantly affected by the conditions of testing, such as posture and time of day. On average, an ARR cutoff of 23.6 ng/dL per ng/(mL·h), expressed in alternative units as 651 pmol/L per μg/(L·h), has been estimated to have a sensitivity of 97% and specificity of 94%.
Aldosterone-Renin Ratio in Primary Hyperaldosteronism
' by Allan S. Brett. Posted: 03/15/2005; Journal Watch. 2005;4(2) An ARR value in an individual that is ''higher'' than the cutoff indicates primary hyperaldosteronism. If the inverse ratio (i.e. renin-to-aldosterone) ratio is used, a value ''lower'' than the cutoff indicates primary hyperaldosteronism.

References

{{reflist Endocrinology

Tests

Interpretation

See also

References