Afloqualone (Arofuto) is a
quinazolinone family
GABAergic
In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic ...
drug
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i ...
and is an analogue of
methaqualone
Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude ( ) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg me ...
developed in the 1970s by a team at Tanabe Seiyaku.
It has
sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...
and
muscle-relaxant effects resulting from its agonist activity at the β subtype of the
GABAa receptor and has had some clinical use, although it causes
photosensitization as a side-effect that can cause skin problems such as
dermatitis
Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened ...
.
See also
*
Diproqualone
*
Etaqualone
*
Methylmethaqualone
*
Mecloqualone
*
Mebroqualone
*
Cloroqualone
*
Nitromethaqualone
References
Sedatives
Muscle relaxants
Organofluorides
Quinazolinones
GABAA receptor positive allosteric modulators
{{sedative-stub