Afadin is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''AFDN''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998). upplied by OMIMref name="entrez">

Interactions

Afadin has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

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BCR gene The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the ''BCR'' gene. ''BCR'' is one of the two genes in the ''BCR-ABL'' fusion protein, which is associated with th ...

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EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the ''EPHB3'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is ...

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F11 receptor Junctional adhesion molecule A is a protein that in humans is encoded by the ''F11R'' gene. It has also been designated as CD321 (cluster of differentiation 321). Function Tight junctions represent one mode of cell-to-cell adhesion in epitheli ...

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HRAS GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the gene. The ''HRAS'' gene is located on the short (p) arm of chromosome 11 (human), chromosome 11 at position 15.5, ...

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LMO2 LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the ''LMO2'' gene. Structure LMO2 is characterized ...

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PVRL1 Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein ...

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PVRL3 Nectin-3, also known as nectin cell adhesion molecule 3, is a protein that in humans is encoded by the ''NECTIN3'' gene. Nectin-3 belongs to the family of immunoglobulin(Ig)-like cellular adhesion molecules involved in Ca2+-independent cellular ...

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Profilin 1 Profilin-1 is a protein that in humans is encoded by the ''PFN1'' gene. Structure The PFN1 protein, also known as profilin-1, is a small, monomeric protein composed of 139–140 amino acids with a molecular mass of approximately 15 kDa. Its ...

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RAP1A Ras-related protein Rap-1A is a protein that in humans is encoded by the ''RAP1A'' gene. Function The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the clas ...

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RAP1GAP Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''RAP1GAP'' gene. Interactions RAP1GAP has been shown to interact with MLLT4 Afadin is a protein that in humans is encoded by the ''AFDN'' gene. Function Afa ...

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SORBS1 CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the ''SORBS1'' gene. It is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and ...

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SSX2IP Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the ''SSX2IP'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleoti ...

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Tight junction protein 1 Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the ''TJP1'' gene in humans. It belongs to the family of ''zonula occludens proteins'' (ZO-1, ZO-2, and ZO-3), which ...

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USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the ''USP9X'' gene. Function This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific protease ...

Function

Interactions

References

Further reading