Afabicin (Debio 1450) is an experimental

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

developed by

Debiopharm Debiopharm is a Privately held company, privately-held Switzerland, Swiss biopharmaceutical company mainly active in drug development, development and Clinical trial, clinical testing of Drug discovery, drug candidates. It was founded in 1979 by ...

for the treatment of ''

Staphylococcus aureus ''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often posi ...

'' infections. It is a

prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ...

which is converted ''in vivo'' into the active form afabicin desphosphono (Debio 1452) which acts as an inhibitor of the staphylococcal

enoyl-acyl carrier protein reductase Enoyl-acyl carrier protein reductase (ENR or FabI) (), is a key enzyme of the type II fatty acid synthesis (FAS) system. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and i ...

(FabI) enzyme. It has shown similar efficacy in

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s to established drugs such as

vancomycin Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. It is administered intravenously ( injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone an ...

, but has not yet been approved for clinical use.

References

{{reflist Antibiotics Acrylamides Benzofurans Naphthyridines Organophosphates

See also

References