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Aetokthonotoxin (AETX), colloquially 'eagle toxin', was discovered in 2021 as the cyanobacterial neurotoxin causing vacuolar myelinopathy (VM) in 
eagles
Eagle is the common name for many large Bird of prey, birds of prey of the family Accipitridae. Eagles belong to several groups of Genus, genera, some of which are closely related. Most of the 68 species of eagle are from Eurasia and Africa. Ou ...
in North America. As the biosynthesis of aetokthonotoxin depends on the availability of bromide in freshwater systems and requires an interplay between the toxin-producing cyanobacterium '' Aetokthonos hydrillicola'' and the host plant it epiphytically grows on (most importantly hydrilla
''Hydrilla'' (waterthyme) is a genus of aquatic plant, usually treated as containing just one species, ''Hydrilla verticillata'', though some botanists divide it into several species. It is native to the cool and warm waters of the Old World in A ...
), it took > 25 years to discover aetokthonotoxin as the VM-inducing toxin after the disease has first been diagnosed in bald eagles in 1994. The toxin cascades through the food-chain: Among other animals, it affects fish and waterfowl such as coots or ducks which feed on hydrilla
''Hydrilla'' (waterthyme) is a genus of aquatic plant, usually treated as containing just one species, ''Hydrilla verticillata'', though some botanists divide it into several species. It is native to the cool and warm waters of the Old World in A ...
colonized with the cyanobacterium. Aetokthonotoxin is transmitted to raptors, such as the bald eagle
The bald eagle (''Haliaeetus leucocephalus'') is a bird of prey found in North America. A sea eagle, it has two known subspecies and forms a species pair with the white-tailed eagle (''Haliaeetus albicilla''), which occupies the same nich ...
, that prey on these affected animals. The total synthesis of AETX has been achieved in 2021, the enzymatic functions of the 5 enzymes involved in AETX biosynthesis were described in 2022.
See also
*Cyanotoxin
Cyanotoxins are toxins produced by cyanobacteria (also known as blue-green algae). Cyanobacteria are found almost everywhere, but particularly in lakes and in the ocean where, under high concentration of phosphorus conditions, they reproduce exp ...
References
{{Neurotoxins Neurotoxins Cyanotoxins Bacterial alkaloids Nitriles Bromoarenes Indoles