A-86929 is a synthetic compound that acts as a selective
dopamine receptor D1 agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
.
It was developed as a possible treatment for
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
,
as well as for other applications such as treatment of
cocaine addiction,
but while it had reasonable efficacy in humans it also caused
dyskinesias and has not been continued.
It has mainly been used as its di
acetate
An acetate is a salt formed by the combination of acetic acid with a base (e.g. alkaline, earthy, metallic, nonmetallic, or radical base). "Acetate" also describes the conjugate base or ion (specifically, the negatively charged ion called ...
ester
In chemistry, an ester is a compound derived from an acid (either organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (R). These compounds contain a distin ...
prodrug adrogolide (ABT-431), which has better bioavailability.
References
D1 receptor agonists
Thiophenes
Catechols
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