A-86929 is a synthetic compound that acts as a selective
dopamine receptor D1 agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
.
It was developed as a possible treatment for
Parkinson's disease,
as well as for other applications such as treatment of
cocaine addiction,
but while it had reasonable efficacy in humans it also caused
dyskinesias and has not been continued.
It has mainly been used as its di
acetate
An acetate is a salt (chemistry), salt formed by the combination of acetic acid with a base (e.g. Alkali metal, alkaline, Alkaline earth metal, earthy, Transition metal, metallic, nonmetallic or radical Radical (chemistry), base). "Acetate" als ...
ester prodrug
A prodrug is a medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug ...
adrogolide (ABT-431), which has better bioavailability.
References
D1-receptor agonists
Thiophenes
Catechols
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