Adi Utarini
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Adi Utarini is an Indonesian public health researcher who works on disease control of
dengue fever Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. Asymptomatic infections are uncommon, mild cases happen frequently; if symptoms appear, they typically begin 3 to 14 days after i ...
. She serves as Professor of Public Health in the Department of Health and Policy Management at
Gadjah Mada University Gadjah Mada University (; , abbreviated as UGM) is a public research university located in Sleman, Special Region of Yogyakarta, Indonesia. Officially founded on 19 December 1949, Gadjah Mada University is one of the oldest and largest institut ...
,
Yogyakarta Yogyakarta is the capital city of the Special Region of Yogyakarta in Indonesia, in the south-central part of the island of Java. As the only Indonesian royal city still ruled by Hamengkubuwono, a monarchy, Yogyakarta is regarded as an importan ...
. In 2020, she was selected as one of ''Nature'' 10 for pioneering the
randomized controlled trial A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical ...
of a
dengue Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. Asymptomatic infections are uncommon, mild cases happen frequently; if symptoms appear, they typically begin 3 to 14 days after ...
prevention technique using mosquitoes carrying the ''
Wolbachia ''Wolbachia'' is a genus of gram-negative bacteria infecting many species of arthropods and filarial nematodes. The symbiotic relationship ranges from parasitism to obligate mutualism. It is one of the most common parasitic microbes of arthrop ...
'' bacteria. In 2021, she was selected as one o
TIME's 100 most Influential People of 2021


Early life and education

Utarini was born in Yogyakarta on 4 June 1965. She studied medicine at the
Gadjah Mada University Gadjah Mada University (; , abbreviated as UGM) is a public research university located in Sleman, Special Region of Yogyakarta, Indonesia. Officially founded on 19 December 1949, Gadjah Mada University is one of the oldest and largest institut ...
,
Yogyakarta Yogyakarta is the capital city of the Special Region of Yogyakarta in Indonesia, in the south-central part of the island of Java. As the only Indonesian royal city still ruled by Hamengkubuwono, a monarchy, Yogyakarta is regarded as an importan ...
, Indonesia. After graduating in 1989 she completed two master's degrees, one at the
UCL Great Ormond Street Institute of Child Health The UCL Great Ormond Street Institute of Child Health (ICH) is an academic department of the Faculty of Population Health Sciences of University College London (UCL) and is located in London, United Kingdom. It was founded in 1946 and together ...
,
United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotlan ...
(1994) and one at
Umeå University Umeå University (; Ume Sami language, Ume Sami: ) is a public university, public research university located in Umeå, in the mid-northern region of Sweden. The university was founded in 1965 and is the fifth oldest within Sweden's present bord ...
,
Sweden Sweden, formally the Kingdom of Sweden, is a Nordic countries, Nordic country located on the Scandinavian Peninsula in Northern Europe. It borders Norway to the west and north, and Finland to the east. At , Sweden is the largest Nordic count ...
(1997). She remained at Umeå for her doctoral research, where she focused on a malaria control programme in
Central Java Central Java (, ) is a Provinces of Indonesia, province of Indonesia, located in the middle of the island of Java. Its administrative capital is Semarang. It is bordered by West Java in the west, the Indian Ocean and the Special Region of Yogya ...
. She completed her doctorate in 2002.


Research and career

Utarini focuses on disease control and healthcare quality at Gadjah Mada University, Yogyakarta, Indonesia. She served as Project Leader fo
World Mosquito Program Yogyakarta
Yogyakarta is a densely populated city of almost 400,000 people with high transmission rates of
dengue fever Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. Asymptomatic infections are uncommon, mild cases happen frequently; if symptoms appear, they typically begin 3 to 14 days after i ...
. In 2018, she delivered a
TEDx talk TED Conferences, LLC (Technology, Entertainment, Design) is an American-Canadian non-profit media organization that posts international talks online for free distribution under the slogan "Ideas Change Everything" (previously "Ideas Worth Sprea ...
on attempts to reduce dengue outbreaks in the city. Utarini co-led a
randomized controlled trial A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical ...
of the technique employing ''
Wolbachia ''Wolbachia'' is a genus of gram-negative bacteria infecting many species of arthropods and filarial nematodes. The symbiotic relationship ranges from parasitism to obligate mutualism. It is one of the most common parasitic microbes of arthrop ...
''-carrying mosquitoes in reducing the spread of mosquito-borne diseases, such as the dengue fever, starting from 2016 in Yogyakarta. In August 2020 she announced that the method reduced the incidence of dengue fever by 77% during the trial. The ''Wolbachia'' bacterium prevents mosquitoes from passing viruses to humans. While the method had been developed since the 1990s at the
Monash University Monash University () is a public university, public research university based in Melbourne, Victoria (state), Victoria, Australia. Named after World War I general Sir John Monash, it was founded in 1958 and is the second oldest university in the ...
,
Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...
, the trial was "the strongest evidence yet" to support its impact, and the first randomized control trial of this approach. In the trial, the city of Yogyakarta was divided into 24 clusters—12 randomly selected to receive the ''Wolbachia''-infected mosquitoes and the rest to serve as control. As of December 2020, the full data had not been published, but the data was unblinded in June 2020 and a preliminary result was released in August, which showed the 77% reduction in the areas where the ''Wolbachia''-modified mosquitoes were released compared to the control area. Epidemiologists praised the result as "staggering" and "epochal", and an important step in the fight against dengue, which causes about 400 million infections and 25,000 deaths annually, as well as possibly other mosquito-carried diseases. Utarini was recruited to the effort in 2013, becoming the Indonesia lead scientist of the project. In addition to coordinating the trial, she played an important role in securing the regulatory approval from multiple government ministries. Throughout the trial, Utarini had to gain the support of the local community, which she achieved through wall paintings, short films and face-to-face meetings; the eagerness of the community to participate was one of the successful aspects of the trial. Between 2015 and 2017 she served in the Research Council of the Indonesian
Ministry of Research and Technology Ministry may refer to: Government * Ministry (collective executive), the complete body of government ministers under the leadership of a prime minister * Ministry (government department), a department of a government Religion * Christian mi ...
. In 2020 Utarini was selected as one of ''Nature'' 10 for pioneering the ''Wolbachia'' mosquito trials. On 13 October 2021, she appointed as Member of BRIN Steering Committee by
Joko Widodo Joko Widodo (; born 21 June 1961), often known mononymously as Jokowi, is an Indonesian politician, engineer, and businessman who served as the seventh president of Indonesia from 2014 to 2024. Previously a member of the Indonesian Democratic ...
.


Personal life

Utarini is known affectionately as "Prof Uut", and is described by colleagues as quiet but persuasive. Her hobbies include cycling and playing the piano. Utarini was married to Iwan Driprahasto, a professor of
pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...
, also at Gadjah Mada. He died of
coronavirus disease Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from ...
in March 2020.


Select publications

* * * Alongside scientific publications, Utarini has written for ''The Conversation''.


Awards

* Civil Service Long Service Medal, 2nd class (2014)


References

{{DEFAULTSORT:Utarini, Adi Living people 1965 births 21st-century Indonesian women scientists Indonesian women academics Gadjah Mada University alumni Alumni of University College London Umeå University alumni Academic staff of Gadjah Mada University Women epidemiologists