Adenoma sebaceum, also known as facial angiofibroma is a misnamed cutaneous disorder consisting of

angiofibroma Angiofibroma (AGF) is a descriptive term for a wide range of benign skin or mucous membrane (i.e. the outer membrane lining body cavities such as the mouth and nose) lesions in which individuals have: # benign papules, i.e. pinhead-sized elevatio ...

s that begin in childhood (generally present between 2–5 years of age) and appear clinically as red

papule A papule is a small, well-defined bump in the skin lesion, skin. It may have a rounded, pointed or flat top, and may have a umbilication, dip. It can appear with a Peduncle (anatomy), stalk, be thread-like or look warty. It can be soft or firm a ...

s on the face especially on the nasolabial folds, cheek and chin,Marks, James G; Miller, Jeffery (2006). ''Lookingbill and Marks' Principles of Dermatology'' (4th ed.). Elsevier Inc. . often misidentified as acne not responding to treatment. Adenoma sebaceum may at times be associated with

tuberous sclerosis Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combinatio ...

. Gradually the papules become more prominent with time and persist throughout life. Cosmetic removal by

argon Argon is a chemical element; it has symbol Ar and atomic number 18. It is in group 18 of the periodic table and is a noble gas. Argon is the third most abundant gas in Earth's atmosphere, at 0.934% (9340 ppmv). It is more than twice as abu ...

or pulse dye laser or scalpel is indicated.

Signs and symptoms

Adenoma sebaceum are several tiny, pinkish, erythematous hamartomas that cover the nose and cheeks in a distinctive butterfly pattern during early childhood or infancy. They typically occur in the nasolabial folds and are symmetrical.

Diagnosis

Adenoma sebaceum presence represents one of the major diagnostic criteria to confirm the diagnosis of

. When adenoma sebaceum presents with

seizures A seizure is a sudden, brief disruption of brain activity caused by abnormal, excessive, or synchronous neuronal firing. Depending on the regions of the brain involved, seizures can lead to changes in movement, sensation, behavior, awareness, o ...

and

mental retardation Intellectual disability (ID), also known as general learning disability (in the United Kingdom), and formerly mental retardation (in the United States), Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010).Archive is a generalized neurodevelopmental ...

(Vogt's triad), it indicates that cranial imaging is necessary, other differential diagnoses for this disorder include

acne vulgaris Acne ( ), also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, ...

rhinophyma Rhinophyma is a condition causing development of a large, bulbous nose associated with granulomatous infiltration, commonly due to untreated rosacea. The condition is most common in older white males. Colloquial terms for the rhinophyma include ...

, and

sebaceous hyperplasia Sebaceous hyperplasia is a disorder of the sebaceous glands in which they become enlarged, producing flesh-colored or yellowish, shiny, often umbilicated bumps. Sebaceous hyperplasia, primarily affecting older patients in high-concentration areas l ...

Treatment

Adenoma sebaceum can be eliminated with

dermabrasion Dermabrasion is a type of surgical skin planing, generally with the goal of removing acne, scarring and other skin or tissue irregularities, typically performed in a professional medical setting by a dermatologist or plastic surgeon trained spec ...

or a laser.

References

External links

GPnotebook
{{Skin tumors, dermis Dermal and subcutaneous growths

Signs and symptoms

Diagnosis

Treatment

See also

References

Further reading

External links