Adam Castillejo (born 1979 or 1980), also known as "The London Patient",
is the second person known to have been cured of
HIV
The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the im ...
infection.
Castillejo, who is British-Venezuelan
and has mixed European ancestry, lives in London. He has previously worked as a chef and is now a motivational speaker.
Diagnosed in 2003, his body became resistant to HIV infection after receiving a
bone marrow transplant
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce a ...
in 2016 to treat
Hodgkin's lymphoma
Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the lymph nodes. The condition was named a ...
. The German donor carried the
CCR5-Δ32
CCR5-Δ32 (or CCR5-D32 or CCR5 delta 32) is a genetic variant of the CCR5 gene characterized by a 32-base-pair deletion that produces a nonfunctional receptor on the surface of immune cells, conferring strong resistance to HIV-1 infection in indi ...
mutation which gives resistance from HIV infection.
It is likely because of his half-Dutch father that Adam’s donor was compatible with him. He was treated by Professor
Ravindra Gupta.
[
]
See also
* Timothy Ray Brown
Timothy Ray Brown (March 11, 1966September 29, 2020) was an American considered to be the first person cured of HIV/AIDS. Brown was called "The Berlin Patient" at the 2008 Conference on Retroviruses and Opportunistic Infections, where his cure ...
* Stephen Crohn
Stephen Lyon Crohn (September 5, 1946 – August 23, 2013), also known as "the man who can't catch AIDS", was a man notable for a genetic mutation that caused him to be immune to AIDS. He was a great-nephew of Burrill Bernard Crohn, for whom Cr ...
* Innate resistance to HIV
A small proportion of humans show partial or apparently complete innate resistance to HIV, the virus that causes AIDS. The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the propor ...
* Long term nonprogressor
* HIV/AIDS research
HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV.
Transmission
A body of sc ...
References
Living people
Year of birth missing (living people)
People with HIV/AIDS
People from Caracas
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