Acoltremon sold under the brand name Tryptyr, is a
medication
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmaco ...
used for the treatment of
dry eye syndrome
Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occas ...
.
Medical uses
Acoltremon was approved for medical use in the United States in May 2025, for the treatment of signs and symptoms associated with dry eye disease.
Pharmacology
Acoltremon acts as a potent and selective activator (
opener
Opener, Open'er or Openers may refer to:
* Opener (album), ''Opener'' (album), an album by 8mm
* Opener (baseball), a baseball strategy to use a relief pitcher to start a game
* Open'er Festival, a contemporary music festival held in Gdynia, Poland ...
) of the
TRPM8
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular ...
calcium channel, which is responsible for the sensation of coldness produced by
menthol
Menthol is an organic compound, specifically a Monoterpene, monoterpenoid, that occurs naturally in the oils of several plants in the Mentha, mint family, such as Mentha arvensis, corn mint and peppermint. It is a white or clear waxy crystallin ...
.
It is slightly less potent as a TRPM8 activator compared to
icilin, but is a much more selective TRPM8 ligand when compared to menthol.
Society and culture
Legal status
Acoltremon was approved for medical use in the United States in May 2025.
References
External links
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Ophthalmology drugs
Ion channel openers
Amides
Cooling flavors
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