Acetoxyacetylaminofluorene is a derivative of
2-acetylaminofluorene
2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in the study of carcinogenesis. It induces tumors in a number of species in the liver, bladder and kidney. The metabolism ...
used as a biochemical tool in the study of
carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cell (biology), cells are malignant transformation, transformed into cancer cells. The process is characterized by changes at the cellular, G ...
. It forms adducts with DNA by reacting with
guanine
Guanine () (symbol G or Gua) is one of the four main nucleotide bases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine ( uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside ...
at its C-8 position.;
[ This results in breaks in one strand of the DNA.
]
See also
* Hydroxyacetylaminofluorene
References
{{Organic-compound-stub
Carcinogens