Aceclidine (Glaucostat, Glaunorm, Glaudin) is a
parasympathomimetic
A parasympathomimetic drug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic nervous system (PSNS). These chemicals are also called cholinergic drugs because acet ...
agent used in the treatment of narrow angle
glaucoma
Glaucoma is a group of eye diseases that result in damage to the optic nerve (or retina) and cause vision loss. The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye re ...
. It decreases
intraocular pressure
Intraocular pressure (IOP) is the fluid pressure inside the eye
Eyes are organs of the visual system. They provide living organisms with vision, the ability to receive and process visual detail, as well as enabling several photo response fu ...
.
Adverse effects
Side effects of aceclidine include increased salivation and
bradycardia
Bradycardia (also sinus bradycardia) is a slow resting heart rate, commonly under 60 beats per minute (BPM) as determined by an electrocardiogram. It is considered to be a normal heart rate during sleep, in young and healthy or elderly adults, ...
(in excessive doses).
Mechanism of action
Aceclidine acts as a
muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor, G protein-coupled receptor complexes in the cell membranes of certain neurons and other Cell (biology), cells. They play several r ...
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
.
See also
*
Talsaclidine
Talsaclidine (WAL-2014) is a non- selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes. It was under development for the treatment of Alzheimer' ...
(drug with a similar structure)
*
Muscarine
Muscarine, L-(+)-muscarine, or muscarin is a natural product found in certain mushrooms, particularly in '' Inocybe'' and '' Clitocybe'' species, such as the deadly '' C. dealbata''. Mushrooms in the genera '' Entoloma'' and '' Mycena'' hav ...
References
{{Muscarinic acetylcholine receptor modulators
Acetate esters
Muscarinic agonists
Ophthalmology drugs
3-Quinuclidinyl esters
Drugs in the Soviet Union
Soviet inventions