Abediterol (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...

; development codes AZD-0548 and LAS 100977) is a once-daily experimental drug candidate for the treatment of

asthma Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wh ...

and

chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. GOLD defines COPD as a heterogeneous lung condition characterized by chronic respiratory s ...

(COPD), but it has never been marketed.

History

Abediterol was under

development Development or developing may refer to: Arts *Development (music), the process by which thematic material is reshaped * Photographic development *Filmmaking, development phase, including finance and budgeting * Development hell, when a proje ...

by the Spanish pharmaceutical company

Almirall Almirall, S.A. is a Spanish pharmaceutical company dedicated to medical dermatology, with headquarters in Barcelona, founded in 1944. In 2023, the company generated total revenues of €898.8 million and was the leading European company in medi ...

and reached Phase II clinical trials, but was discontinued in 2021. Its coformulation with

mometasone furoate Mometasone, also known as mometasone furoate, is a steroid (specifically, a glucocorticoid) medication used to treat certain skin conditions, hay fever, and asthma. Specifically it is used to prevent rather than treat asthma attacks. It can be ...

also progressed to Phase II clinical trials, but was discontinued in 2019.

Mechanism of action

Abediterol is an ultra-long-acting β₂ agonist (ultra-LABA).

References

Long-acting beta2-adrenergic agonists Muscarinic antagonists Organofluorides 2-Quinolones Hydroxyarenes Phenylethanolamines Abandoned drugs {{respiratory-system-drug-stub