Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, also known as alpha-aminoadipate aminotransferase and kynurenine aminotransferase 2, is a
mitochondrial
A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used ...
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''AADAT'' gene. It converts alpha-aminoadipate to alpha-ketoadipate. It is also one of the
Kynurenine—oxoglutarate transaminase
In enzymology, a kynurenine-oxoglutarate transaminase () is an enzyme that catalyzes the chemical reaction
:-kynurenine + 2-oxoglutarate 4-(2-aminophenyl)-2,4-dioxobutanoate + -glutamate
Thus, the two substrates of this enzyme are -kynurenin ...
s.
References
External links
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PDBe-KBprovides an overview of all the structure information available in the PDB for Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)
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