Autophagy-related protein 9A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ATG9A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Functional studies indicate that ATG9A plays a role in
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
.
and other non-autophagy membrane remodeling processes such as
plasma membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extr ...
repair.
Enzymatically, it is a lipid
scramblase
Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins tha ...
.
ATG9A interacts with
IQGAP1
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the ''IQGAP1'' gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging fro ...
and the
ESCRT
The endosomal sorting complexes required for transport (ESCRT) proteins are part of a group of machines inside cells that help sort and move other proteins. One of their main jobs is to form structures called multivesicular bodies (MVBs) which help ...
machinery in membrane remodeling.
References
Further reading
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External links
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