P01A Agents against
amoebiasis Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba '' Entamoeba histolytica''. Amoebiasis can be present with no, mild, or severe symptoms. Symptoms may include lethargy, loss of weight, colon ...
and other
protozoa Protozoa (: protozoan or protozoon; alternative plural: protozoans) are a polyphyletic group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic debris. Historically ...
l diseases

P01AA Hydroxyquinoline derivatives

:P01AA01 Broxyquinoline :P01AA02

Clioquinol Clioquinol (iodochlorhydroxyquin) tradename Entero-Vioform is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA ...

:P01AA04 Chlorquinaldol :P01AA05 Tilbroquinol :P01AA30 Tilbroquinol and tiliquinol :P01AA52 Clioquinol, combinations

P01AB
Nitroimidazole Nitroimidazoles are the group of organic compound, organic compounds consisting of an imidazole ring with at least one nitro group substituent. The term also refers to the class of antibiotics that have nitroimidazole in their structures. These an ...
derivatives

:P01AB01

Metronidazole Metronidazole, sold under the brand name Flagyl and Metrogyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vagino ...

:P01AB02

Tinidazole Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infecti ...

:P01AB03

Ornidazole Ornidazole is an antibiotic used to treat protozoan infections. A synthetic nitroimidazole, it is commercially obtained from an acid-catalyzed reaction between 2-methyl-5-nitroimidazole and epichlorohydrin. Ornidazole is nothing but chloro-secn ...

:P01AB04

Azanidazole Azanidazole is a nitroimidazole derivative used in gynecology Gynaecology or gynecology (see American and British English spelling differences) is the area of medicine concerned with conditions affecting the Female reproductive system, female ...

:P01AB05 Propenidazole :P01AB06

Nimorazole Nimorazole (INN) is a nitroimidazole anti-infective. It is also being investigated for the treatment of head and neck cancer Head and neck cancer is a general term encompassing multiple cancers that can develop in the head and neck region. The ...

:P01AB07

Secnidazole Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective used to treat bacterial vaginosis and trichomoniasis. It is taken orally. Structurally it actually methyl-metronidazole. Effectiveness in the tr ...

:P01AB08 Satranidazole :P01AB51 Metronidazole and furazolidone :P01AB52 Metronidazole and diloxanide :P01AB53 Tinidazole and diloxanide

P01AC
Dichloroacetamide Dichloroacetamide is a organochloride, chlorinated derivative of acetamide. References
Dichloromethyl compounds Acetamides {{organic-compound-stub ...
derivatives

:P01AC01 Diloxanide :P01AC02 Clefamide :P01AC03 Etofamide :P01AC04

Teclozan Teclozan is an antiprotozoal agent. It is a dichloroacetamide Dichloroacetamide is a organochloride, chlorinated derivative of acetamide. References Dichloromethyl compounds Acetamides {{organic-compound-stub .... References Dichloro ...

P01AR
Arsenic Arsenic is a chemical element; it has Symbol (chemistry), symbol As and atomic number 33. It is a metalloid and one of the pnictogens, and therefore shares many properties with its group 15 neighbors phosphorus and antimony. Arsenic is not ...
compounds

:P01AR01 Arsthinol :P01AR02 Difetarsone :P01AR03 Glycobiarsol :P01AR53 Glycobiarsol, combinations

P01AX Other agents against amoebiasis and other protozoal diseases

:P01AX01 Chiniofon :P01AX02

Emetine Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. It takes its name from its emetic properties. Early preparations Mechanism of action of emetine was studied by François Magendie duri ...

:P01AX04 Phanquinone :P01AX05

Mepacrine Mepacrine, also called quinacrine or by the trade names Atabrine or Atebrin, is a medication with several uses. It is related to chloroquine and mefloquine. Although available from compounding pharmacies, as of August 2020 approved formulations ...

:P01AX06

Atovaquone Atovaquone, sold under the brand name Mepron, is an antimicrobial medication for the prevention and treatment of ''Pneumocystis jirovecii'' pneumonia (PCP). Atovaquone is a chemical compound that belongs to the class of naphthoquinones. Atova ...

:P01AX07

Trimetrexate Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. Uses It has been used with leucovorin in treating pneumocystis pneumonia. It has been investigated for use in treating leiomyosarcoma. It is a methotrexate ...

:P01AX08 Tenonitrozole :P01AX09

Dehydroemetine Dehydroemetine is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure (they differ only in a double bond next to the ethyl substituent), but it produces fewer side effects. In the United S ...

:P01AX10

Fumagillin Fumagillin is a complex biomolecule and used as an antimicrobial agent. It was isolated in 1949 from the microbial organism ''Aspergillus fumigatus''. Uses In animals It was originally used against microsporidian parasites ''Nosema apis'' infect ...

:P01AX11

Nitazoxanide Nitazoxanide, sold under the brand name Alinia among others, is a broad-spectrum antiparasitic and broad-spectrum antiviral medication that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is ...

:P01AX52 Emetine, combinations

P01B Anti
malaria Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomitin ...
ls

P01BA
Aminoquinoline Aminoquinolines are derivatives of quinoline, most notable for their roles as antimalarial drugs. Depending upon the location of the amino In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed w ...
s

:P01BA01

Chloroquine Chloroquine is an antiparasitic medication that treats malaria. It works by increasing the levels of heme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading. Certain types ...

:P01BA02

Hydroxychloroquine Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, an ...

:P01BA03

Primaquine Primaquine is a medication used to treat and prevent malaria and to treat ''Pneumocystis'' pneumonia. Specifically it is used for malaria due to ''Plasmodium vivax'' and '' Plasmodium ovale'' along with other medications and for prevention if ot ...

:P01BA06

Amodiaquine Amodiaquine (ADQ) is a medication used to treat malaria, including ''Plasmodium falciparum'' malaria when uncomplicated. It is recommended to be given with artesunate to reduce the risk of resistance. Due to the risk of rare but serious side ef ...

:P01BA07

Tafenoquine Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria. With respect to acute malaria, it is used together with other medications to prevent relapse by ''Plasmodium vivax''. It may be ...

P01BB
Biguanide Biguanide () is the organic compound with the formula HN(C(NH)NH2)2. It is a colorless solid that dissolves in water to give a highly basic solution. These solutions slowly hydrolyse to ammonia and urea. Synthesis Biguanide can be obtained fro ...
s

:P01BB01

Proguanil Proguanil, also known as chlorguanide and chloroguanide, is a medication used to treat and prevent malaria. It is often used together with chloroquine or atovaquone. When used with chloroquine the combination will treat mild chloroquine resist ...

:P01BB02 Cycloguanil embonate :P01BB51 Proguanil and atovaquone :P01BB52 Chloroquine and proguanil

P01BC Methanolquinolines

:P01BC01

Quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to ''Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg ...

:P01BC02

Mefloquine Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It ...

P01BD
Diaminopyrimidine Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring. They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim and the anti ...
s

:P01BD01

Pyrimethamine Pyrimethamine, sold under the brand name Daraprim among others, is a medication used with leucovorin (leucovorin is used to decrease side effects of pyrimethamine; it does not have intrinsic anti-parasitic activity) to treat the parasitic disea ...

:P01BD51 Pyrimethamine, combinations

P01BE
Artemisinin Artemisinin () and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to ''Plasmodium falciparum''. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for he ...
and derivatives, plain

:P01BE01

Artemisinin Artemisinin () and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to ''Plasmodium falciparum''. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for he ...

:P01BE02

Artemether Artemether is a medication used for the treatment of malaria. The injectable form is specifically used for severe malaria rather than quinine. In adults, it may not be as effective as artesunate. It is given by injection in a muscle. It is also ...

:P01BE03

Artesunate Artesunate (AS) is a medication used to treat malaria. The intravenous form is preferred to quinine for severe malaria. Often it is used as part of combination therapy, such as artesunate plus mefloquine. It is not used for the prevention of ...

:P01BE04 Artemotil :P01BE05

Artenimol Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available a ...

P01BF Artemisinin and derivatives, combinations

:P01BF01 Artemether and lumefantrine :P01BF02 Artesunate and mefloquine :P01BF03 Artesunate and amodiaquine :P01BF04 Artesunate, sulfalene and pyrimethamine :P01BF05 Artenimol and

piperaquine Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Piperaquine was developed under the Chinese National Malaria Elimination Programme in the 1960s and was adopted throughout China as a replacement ...

:P01BF06 Artesunate and

pyronaridine Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s. In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for chloroquine Chl ...

:P01BF07 Artemisinin and

:P01BF08 Artemisinin and naphthoquine :P01BF09 Artesunate, sulfadoxine and pyrimethamine

P01BX Other antimalarials

:P01BX01

Halofantrine Halofantrine is a drug used to treat malaria. Halofantrine's structure contains a substituted phenanthrene, and is related to the antimalarial drugs quinine and lumefantrine. Marketed as Halfan, halofantrine is never used to prevent malaria and ...

:P01BX02

Arterolane Arterolane, also known as OZ277 or RBx 11160, is an antimalarial compound marketed by Ranbaxy Laboratories. It was discovered by US and European scientists coordinated by the Medicines for Malaria Venture (MMV). Its molecular structure is uncom ...

and

P01C Agents against
leishmaniasis Leishmaniasis is a wide array of clinical manifestations caused by protozoal parasites of the Trypanosomatida genus ''Leishmania''. It is generally spread through the bite of Phlebotominae, phlebotomine Sandfly, sandflies, ''Phlebotomus'' an ...
and
trypanosomiasis Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus ''Trypanosoma''. In humans this includes African trypanosomiasis and Chagas disease. A number of other disea ...

P01CA
Nitroimidazole Nitroimidazoles are the group of organic compound, organic compounds consisting of an imidazole ring with at least one nitro group substituent. The term also refers to the class of antibiotics that have nitroimidazole in their structures. These an ...
derivatives

:P01CA02

Benznidazole Benznidazole is an antiparasitic medication used in the treatment of Chagas disease. While it is highly effective in early disease, the effectiveness decreases in those who have long-term infection. It is the first-line treatment given its mod ...

:P01CA03

Fexinidazole Fexinidazole is a medication used to treat African trypanosomiasis (sleeping sickness) caused by ''Trypanosoma brucei gambiense''. It is effective against both first and second stage disease. It is taken by mouth. Common side effects includ ...

P01CB
Antimony Antimony is a chemical element; it has chemical symbol, symbol Sb () and atomic number 51. A lustrous grey metal or metalloid, it is found in nature mainly as the sulfide mineral stibnite (). Antimony compounds have been known since ancient t ...
compounds

:P01CB01 Meglumine antimonate :P01CB02 Sodium stibogluconate

P01CC Nitrofuran derivatives

:P01CC01

Nifurtimox Nifurtimox, sold under the brand name Lampit, is a medication used to treat Chagas disease and sleeping sickness. For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. In Chagas disease ...

:P01CC02

Nitrofural Nitrofurazone (INN, trade name Furacin) is an antimicrobial organic compound belonging to the nitrofuran class. It is most commonly used as a topical antibiotic ointment. It is effective against gram-positive bacteria, gram-negative bacteria, ...

P01CD Arsenic compounds

:P01CD01

Melarsoprol Melarsoprol is an arsenic-containing medication used for the treatment of sleeping sickness (African trypanosomiasis). It is specifically used for second-stage disease caused by '' Trypanosoma brucei rhodesiense'' when the central nervous system ...

:P01CD02

Acetarsol Acetarsol (or acetarsone) is an anti- infective drug. It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol. It has been given in the form of suppositories. Acetarsol can be used to ma ...

P01CX Other agents against leishmaniasis and trypanosomiasis

:P01CX01 Pentamidine isethionate :P01CX02 Suramin sodium :P01CX03

Eflornithine Eflornithine, sold under the brand name Vaniqa among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women. Specifically it is used for the second stage of sleeping sic ...

:P01CX04

Miltefosine Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as '' Naegleria fowleri'' and '' Balamuthia mandrillaris''. This includes the three forms of ...

References

{{Agents against amoebozoa P01

P01AA Hydroxyquinoline derivatives

P01AB Nitroimidazole Nitroimidazoles are the group of organic compound, organic compounds consisting of an imidazole ring with at least one nitro group substituent. The term also refers to the class of antibiotics that have nitroimidazole in their structures. These an ... derivatives

P01AC Dichloroacetamide Dichloroacetamide is a organochloride, chlorinated derivative of acetamide. References Dichloromethyl compounds Acetamides {{organic-compound-stub ... derivatives

P01AR Arsenic Arsenic is a chemical element; it has Symbol (chemistry), symbol As and atomic number 33. It is a metalloid and one of the pnictogens, and therefore shares many properties with its group 15 neighbors phosphorus and antimony. Arsenic is not ... compounds