L03A Immunostimulants

L03AA Colony stimulating factors

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Filgrastim Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause. It may ...

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Molgramostim Molgramostim is a recombinant granulocyte macrophage colony-stimulating factor which functions as an immunostimulator Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system usua ...

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Sargramostim Sargramostim (tradename Leukine) is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as an immunostimulator. Medical uses Sargramostim is primarily used for myeloid reconstitution after autologous or allo ...

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Lenograstim Lenograstim is a recombinant granulocyte colony-stimulating factor Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulo ...

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Ancestim Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008.Amgen press officeBiovitrum Closes Product Acquisition Deal ...

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Pegfilgrastim Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the production of white blood cells (neutrophils) ...

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Lipegfilgrastim Lipegfilgrastim, sold under the brand name Lonquex, is a medication used to reduce the duration of neutropenia and the incidence of febrile neutropenia in adults. Text was copied from this source which is copyright European Medicines Agency. R ...

:L03AA15 Balugrastim :L03AA16 Empegfilgrastim :L03AA17 Pegteograstim :L03AA18

Efbemalenograstim alfa Efbemalenograstim alfa, sold under the brand name Ryzneuta, is a medication used to decrease the incidence of infection in chemotherapy-induced neutropenia. It is a leukocyte growth factor. It is given by subcutaneous injection. The most comm ...

:L03AA19 Eflapegrastim :QL03AA90 Pegbovigrastim

L03AB Interferons

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Interferon alfa Interferon alfa ( INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa co ...

natural :L03AB02

Interferon beta The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T cell, T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p2 ...

natural :L03AB03

Interferon gamma Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. ...

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Interferon alfa-2a Pegylated interferon alfa-2a, sold under the brand name Pegasys among others, is medication used to treat hepatitis C and hepatitis B. For hepatitis C it is typically used together with ribavirin and cure rates are between 24 and 92%. For hepat ...

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Interferon alfa-2b Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in ''E. coli'' in the laboratory of Charles Weissmann at the Universi ...

:L03AB06 Interferon alfa-n1 :L03AB07

Interferon beta-1a Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian cells, while interferon beta-1b is produced in modified ''E. coli''. Some research indic ...

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Interferon beta-1b Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS). It is approved for use after the first MS event. Closely related is interferon beta 1a, als ...

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Interferon alfacon-1 Interferon alfacon-1 is a recombinant synthetic type I interferon used for the treatment of hairy cell leukemia, malignant melanoma and AIDS-related Kaposi's sarcoma Kaposi's sarcoma (KS) is a type of cancer that can form masses on the skin, ...

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Peginterferon alfa-2b Pegylated interferon alfa-2b is a drug used to treat melanoma, as an adjuvant therapy to surgery. Also used to treat hepatitis C (typically, in combination with ribavirin), it is no longer recommended due to poor efficacy and adverse side-effect ...

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Peginterferon alfa-2a Pegylated interferon alfa-2a, sold under the brand name Pegasys among others, is medication used to treat hepatitis C and hepatitis B. For hepatitis C it is typically used together with ribavirin and cure rates are between 24 and 92%. For hepat ...

:L03AB12 Albinterferon alfa-2b :L03AB13

Peginterferon beta-1a Peginterferon beta-1a, sold under the brand name Plegridy, is medication used to treat multiple sclerosis. The most common side effects include headache, muscle pain, joint pain, influenza (flu)-like symptoms, pyrexia (fever), chills, asthe ...

:L03AB14 Cepeginterferon alfa-2b :L03AB15 Ropeginterferon alfa-2b :L03AB16

Peginterferon alfacon-2 Peginterferon-alfa may refer to: * Peginterferon alfa-2a, an antiviral drug used in treatment for hepatitis C and hepatitis B * Peginterferon alfa-2b, a treatment for hepatitis C See also * Interferon Interferons (IFNs, ) are a group of s ...

:L03AB17 Sampeginterferon beta-1a :L03AB60 Peginterferon alfa-2b, combinations :L03AB61 Peginterferon alfa-2a, combinations :QL03AB90 Interferom omega, feline origin

L03AC Interleukins

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Aldesleukin Interleukin-2 (IL-2) is an interleukin Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome enc ...

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Oprelvekin Oprelvekin is recombinant interleukin eleven (IL-11), a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in in ...

L03AX Other immunostimulants

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Lentinan Lentinan is a polysaccharide isolated from the fruit body of shiitake mushroom (''Lentinula edodes''). Chemistry Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (N ...

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Roquinimex Linomide (Roquinimex) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha. Linomide has been investigated as a treatment for ...

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BCG vaccine The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). It is named after its inventors Albert Calmette and Camille Guérin. In countries where tuberculosis or leprosy is common, one dose is recom ...

:L03AX04 Pegademase :L03AX05

Pidotimod Pidotimod is an immunostimulant Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system usually in a non-specific manner by inducing activation or increasing activity of any of its ...

:L03AX07 Poly I:C :L03AX08 Poly ICLC :L03AX09

Thymopentin Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time und ...

:L03AX10 Immunocyanin :L03AX11

Tasonermin Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors o ...

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Melanoma vaccine A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. Vaccines that treat existing cancer are known as ''therapeutic'' cancer vaccines or tumor antigen vaccines. Some of the vaccines ...

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Glatiramer acetate Glatiramer acetate, sold under the brand name Copaxone among others, is an immunomodulator medication used to treat multiple sclerosis. Glatiramer acetate is approved in the United States to reduce the frequency of relapses, but not for reduci ...

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Histamine dihydrochloride Histamine dihydrochloride (trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML). It is also an FDA-approved active ingredient for topical analges ...

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Mifamurtide Mifamurtide (trade name Mepact, marketed by Takeda Pharmaceutical Company, Takeda) is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults, which is lethal in over half of cases. The drug was approved in E ...

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Plerixafor Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The ...

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Sipuleucel-T Sipuleucel-T, sold under the brand name Provenge, developed by Dendreon Pharmaceuticals, LLC, is a cell-based cancer immunotherapy for prostate cancer (CaP). It is an autologous cellular immunotherapy. Medical uses Sipuleucel-T is indicated f ...

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Cridanimod Cridanimod, also known as cycloferon or meglumine acridone acetate, is a low molecular weight immunomodulatory drug known to trigger the production of interferons, which are proteins that play a crucial role in the immune response against vira ...

:L03AX19 Dasiprotimut-T :L03AX21

Elapegademase Elapegademase, sold under the brand name Revcovi, is a medication for the treatment of the rare disease adenosine deaminase deficiency- SCID in children and adults. It is a recombinant enzyme that is administered weekly by intramuscular injectio ...

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Leniolisib Leniolisib (INN), sold under the brand name Joenja, is a medication used for the treatment of activated phosphoinositide 3-kinase delta syndrome (APDS). It is a kinase inhibitor that is taken by mouth. The most common side effects include he ...

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Motixafortide Motixafortide, sold under the brand name Aphexda, is a medication used for the treatment of multiple myeloma. Motixafortide is a hematopoietic stem cell mobilizer and a CXCR4 antagonist. It is given by subcutaneous injection. The most common ...

:L03AX24 Mavorixafor :QL03AX90 Feline

interleukin-2 Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a 15.5–16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) ...

recombinant canarypox virus (

viral vector A viral vector is a modified virus designed to gene delivery, deliver genetic material into cell (biology), cells. This process can be performed inside an organism or in cell culture. Viral vectors have widespread applications in basic research, ...

)

References

{{Immunostimulants L03