Histone chaperone ASF1A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ASF1A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
Interactions
ASF1A has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
TLK1,
,
[ ]CHAF1B
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the ''CHAF1B'' gene.
Function
Chromatin assembly factor I ( CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of ...
CHAF1A
Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the ''CHAF1A'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides ...
.[
]
References
Further reading
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External links
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{{Gene-6-stub