AS-8112 is a synthetic compound that acts as a selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

at the dopamine receptor subtypes D₂ and D₃, and the

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...

5-HT₃. It has potent antiemetic effects in animal studies and has been investigated for potential medical use.

References

Antiemetics 5-HT3 antagonists Dopamine antagonists Bromoarenes Salicylamide ethers Diazepanes {{gastrointestinal-drug-stub