Apolipoprotein L2 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''APOL2''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. This gene is a member of the apolipoprotein L gene family and

in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found in the

cytosol The cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells ( intracellular fluid (ICF)). It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondri ...

, nucleoplasm and additionally, it is also seen in the

Nuclear bodies Nuclear bodies (also known as nuclear domains or nuclear dots) are biomolecular condensates, membraneless structures found in the Cell nucleus, cell nuclei of eukaryote, eukaryotic cell (biology), cells. Nuclear bodies include Cajal body, Cajal b ...

. The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.

Amino acid sequence

Total

amino acids Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the Proteinogenic amino acid, 22 α-amino acids incorporated into p ...

: 337

Interactions

APOL2 has been shown to interact with: * IFN-γ, * CD81, * TNF-α, * Bcl-2,

Splice variants

ApoL2 has 5 splice variants, *APOL2-001 This transcript has 6 exons, 12 domains and features are annotated, 263 variations are related this and maps to 35 oligo probes. *APOL2-002 This transcript has 5 exons, 12 domains and features are annotated, 263 variations are related with this gene and maps to 37 oligo probes. *APOL2-006 This transcript has 6 exons, is annotated with 3 domains and features, 62 variations are related with this gene and maps to 20 oligo probes. *APOL2-008 This transcript has 6 exons, 12 domains and features are annotated, 331 variations are related with this gene and maps to 32 oligo probes. *APOL2-009 This transcript has 5 exons, 4 domains and features are annotated, 104 variations are related with this gene and maps to 13 oligo probes.

Functions of the ApoL2

*Acute Inflammation Response * Cholesterol Metabolic Process *Lipid Metabolic Process *Maternal Process Involved in Female Pregnancy * Lipid binding * Signalling Receptor Binding * Aging

References

External links