Apolipoprotein A-I-binding protein also known as APOA1BP is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''APOA1BP''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. Progressive encephalopathy with brain edema and/or leukoencephalopathy-1 (PEBEL-1), a rare, lethal, neurometabolic disorder, is caused by mutation in ''NAXE'' gene (''APOA1BP'' being its former name).

Structure

''APOA1BP'' gene is located on chromosome 1, with its specific location being 1q22. The gene contains 6 exons, 5 introns, and spans 2.5 kb. Expression is ubiquitous across all human tissues, with highest observed in kidney, heart, liver, testis, thyroid gland, adrenal gland. APOA1BP contains Yje_FN domain.

Function

APOA1BP binds to

APOA1 Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the ''APOA1'' gene. As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism. Structure ''APOA1'' is located on chromos ...

APOA2 Apolipoprotein A-II is a protein that in humans is encoded by the ''APOA2'' gene. It is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apol ...

, and

high-density lipoprotein High-density lipoprotein (HDL) is one of the five major groups of lipoproteins. Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules (lipids) around the body within the water outside cells. They are t ...

(HDL). In addition, APOA1BP appears to play a role in sperm capacitation. It has been demonstrated that APOA1BP is involved in angiogenesis regulation, by accelerating cholesterol efflux from endothelial cells to HDL. It is known that

zebrafish The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (an ...

''APOA1BP'' ortholog ''Aibp'' is involved in angiogenesis regulation. The protein was also shown to be involved in atherosclerosis protection.

References

{{gene-1-stub