AP-4 complex subunit epsilon-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''AP4E1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The
heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (
AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the ''AP4B1'' gene.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. A ...
) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (
AP4M1), and a small chain, sigma-4 (
AP4S1).
Clinical relevance
It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
External links
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Further reading
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{{gene-15-stub
Genes mutated in mice