AP4B1
   HOME

TheInfoList



OR:

AP-4 complex subunit beta-1 is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''AP4B1''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 ( AP4E1), a medium chain, mu-4 ( AP4M1), and a small chain, sigma-4 ( AP4S1)


Interactions

AP4B1 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with AP4M1.


Clinical relevance

AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.


References


External links

*
PDBe-KB
provides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1


Further reading

* * * * * * * * * {{gene-1-stub