AP-4 complex subunit beta-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''AP4B1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (
AP4E1), a medium chain, mu-4 (
AP4M1), and a small chain, sigma-4 (
AP4S1)
Interactions
AP4B1 has been shown to
interact
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with
AP4M1.
Clinical relevance
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
External links
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PDBe-KBprovides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1
Further reading
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