AP-1 complex subunit gamma-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''AP1G1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Adaptins are important components of
clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the
trans-Golgi network to
lysosome
A lysosome () is a membrane-bound organelle that is found in all mammalian cells, with the exception of red blood cells (erythrocytes). There are normally hundreds of lysosomes in the cytosol, where they function as the cell’s degradation cent ...
s. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
AP1G1 has been shown to
interact with:
*
AP1B1,
*
AP1GBP1,
[
* AP1S1,][
* NECAP2,]RABEP1
Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP1'' gene. It belongs to rabaptin protein family.
Interactions
RABEP1 has been shown to interact with:
* AP1G1,
* GGA1,
* GGA2,
* RAB4A
Ras-r ...
,
References
Further reading
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External links
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{{PDB Gallery, geneid=164
Proteins