The ANTH domain is a membrane binding domain that shows weak specificity for
PtdIns(4,5)P2
Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)''P''2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes. PtdIns(4,5)''P''2 is enriched at the plasma membrane where it is a substrate for a number of ...
. It was found in
AP180 (homologous to CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).
An ANTH domain is also found in
HIP1
Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.
Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a protein domain, domain homologous to the death ef ...
and
HIP1R
Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the ''HIP1R'' gene.
References
Further reading
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, and the PtdIns(4,5)P2 binding sequence is conserved. More information is found o
endocytosis.org
Human proteins containing this domain
HIP1
Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.
Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a protein domain, domain homologous to the death ef ...
;
HIP1R
Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the ''HIP1R'' gene.
References
Further reading
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PICALM
Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the ''PICALM'' gene.
Interactions
PICALM has been shown to interact with CLTC.
Clinical significance
In humans, certain ...
;
SNAP91
Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the ''SNAP91'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''ge ...
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References
Further reading
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External links
* - Calculated spatial position of ANTH domain of CALM protein in membrane
{{DEFAULTSORT:Anth Domain
Protein domains
Peripheral membrane proteins