Acidic leucine-rich nuclear phosphoprotein 32 family member E is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ANP32E''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
The ANP32E gene is located on chromosome 1q22.
In mammalian cells, ANP32E has been shown to be an
H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.
In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis
and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.
See also
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ANP32A,
ANP32B,
ANP32C,
ANP32D
References
External links
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Further reading
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