Angiopoietin-2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ANGPT2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Naturally occurring antagonist for both
ANGPT1
Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific ty ...
and
TIE2
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TEK tyrosine kinase, TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are prote ...
; expressed only at the sites of vascular remodeling; similar to angiopoietin-1
Function
* See
Angiopoietin#Clinical relevance
Interactions
ANGPT2 has been shown to
interact with
TEK tyrosine kinase
Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ''TEK'' gene. Also known as TIE2, it is an angiopoietin receptor.
Function
The TEK receptor tyrosine kinase is expr ...
.
See also
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Angiopoietin
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from pree ...
References
External links
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Further reading
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