Amphiphysin is a
protein that in humans is encoded by the ''AMPH''
gene.
Function
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with
stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.
Amphiphysin is a brain-enriched
protein with an N-terminal
lipid interaction, dimerisation and
membrane bending
BAR domain, a middle
clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of
dynamin to sites of clathrin-mediated
endocytosis
Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested material. E ...
. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin-2 (
BIN1) that does not contain clathrin or adaptor interactions is highly expressed in
muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...
tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.
Interactions
Amphiphysin has been shown to
interact with
DNM1,
,
,
,
[ CABIN1]
See also
* AP180
* Epsin
References
Further reading
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External links
Bringing your curves to the bar, amphiphysin home page
* {{UCSC gene info, AMPH
Proteins