AMG-3 (part of the AM cannabinoid series) is an

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

drug which is a

cannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

. It is a derivative of Δ⁸- THC substituted with a dithiolane group on the 3-position side chain. AMG-3 is a potent agonist at both CB₁ and CB₂

receptors Receptor may refer to: *Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds ...

with a K_i of 0.32 nM at CB₁ and 0.52 nM at CB₂, and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs. It has

sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...

and analgesic effects, with analgesia lasting for up to 36 hours after administration.

References

External links

* {{cannabinoids Cannabinoids Benzochromenes Hydroxyarenes 1,3-Dithiolanes

See also

References

External links