AL-LAD, also known as 6-allyl-6-nor-LSD, is a

psychedelic drug Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluc ...

of the

lysergamide Lysergamides, also known as ergoamides or as lysergic acid amides, are amides of lysergic acid (LA). They are ergolines, with some lysergamides being found naturally in ergot as well as other fungi. Lysergamides are notable in containing embedd ...

family related to

lysergic acid diethylamide Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a Semisynthesis, semisynthetic, Hallucinogen, hallucinogenic compound derived from ergot, known for its powerful psychological effects and ...

(LSD). It was first described by 1976. Subsequently, the drug was described by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...

in his 1997 book ''

TiHKAL ''TiHKAL: The Continuation'' is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to '' PiHKAL: A Chemical Love Story'', ''TiHKAL'' is an acronym that stands for "Trypt ...

'' (''Tryptamines i Have Known And Loved''). Later, AL-LAD was encountered as a novel

designer A designer is a person who plans the form or structure of something before it is made, by preparing drawings or plans. In practice, anyone who creates tangible or intangible objects, products, processes, laws, games, graphics, services, or exper ...

recreational drug Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, either for pleasure or for some other casual purpose or pastime. When a psychoactive drug enters the user's body, it induces an Sub ...

by 2015.

Use and effects

AL-LAD is taken orally at similar doses as LSD, but has a slightly shorter duration of 6 to 8hours instead of 8 to 12hours. While AL-LAD has subtly different effects than LSD, and appears to be slightly shorter-lasting, their potencies are similar; an active dose of AL-LAD is reported to be between 50 and 150

microgram In the metric system, a microgram or microgramme is a unit of mass equal to one millionth () of a gram. The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom wh ...

Interactions

Pharmacology

Pharmacodynamics

AL-LAD was about 3.5-fold more potent than LSD in substituting for LSD in drug discrimination tests in rodents. Conversely however, AL-LAD was similar in potency to LSD in humans. In addition to drug discrimination, AL-LAD produces the

head-twitch response The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...

, a behavioral proxy of

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

-like effects, in rodents. It was slightly less potent than LSD in producing the head-twitch response.

Chemistry

AL-LAD does not cause a color change with the

Marquis A marquess (; ) is a nobleman of high hereditary rank in various European peerages and in those of some of their former colonies. The German-language equivalent is Markgraf (margrave). A woman with the rank of a marquess or the wife (or wido ...

, Mecke or Mandelin reagents, but does cause the

Ehrlich's reagent Ehrlich's reagent or Ehrlich reagent is a reagent containing ''p''-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen. Several Ehrlich tests use the reagent in a medical test; so ...

to turn purple because of the presence of the

indole Indole is an organic compound with the formula . Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole ...

moiety in its structure. The drug is synthesized starting from nor-LSD as a precursor, using allyl bromide as a reactant.

History

AL-LAD was first described in the

scientific literature Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical ...

Japanese Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspor ...

researchers in 1976. Subsequently, it was studied by Andrew J. Hoffman and David E. Nichols in 1985.

Society and culture

Recreational use

AL-LAD has a known but short and highly uncommon history of recreational human use, which originated in

Ireland Ireland (, ; ; Ulster Scots dialect, Ulster-Scots: ) is an island in the North Atlantic Ocean, in Northwestern Europe. Geopolitically, the island is divided between the Republic of Ireland (officially Names of the Irish state, named Irelan ...

and the

United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotlan ...

, but spread internationally.

Legal status

AL-LAD is not scheduled by the

United Nations The United Nations (UN) is the Earth, global intergovernmental organization established by the signing of the Charter of the United Nations, UN Charter on 26 June 1945 with the stated purpose of maintaining international peace and internationa ...

Convention on Psychotropic Substances The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February ...

overcome is legal ever that doesn't be sold for recreational usage, could be sold for medical or research purposes like a research chemical..

Denmark

AL-LAD is illegal in Denmark.

France

AL-LAD is illegal in France.

Finland

Listed in a decree of the government's psychoactive substances banned from the consumer market.

Latvia

AL-LAD is possibly illegal in Latvia. Although it isn't specifically scheduled, it may be controlled as an LSD structural analog due to an amendment made on June 1, 2015.

Sweden

The Riksdag added AL-LAD to Narcotic Drugs Punishments Act under ''Swedish schedule I'' (''"substances, plant materials and fungi which normally do not have medical use"'' ) as of January 26, 2016, published by Medical Products Agency (MPA) in regulation ''HSLF-FS 2015:35'' listed as 6-allyl-6-nor-LSD, AL-LAD, and 6-allyl-N,N-dietyl-9,10-didehydroergolin-8-karboxamid.

Switzerland

AL-LAD is illegal in Switzerland.

United Kingdom

AL-LAD is illegal in the UK. On June 10, 2014 the UK

Advisory Council on the Misuse of Drugs The Advisory Council on the Misuse of Drugs (ACMD) is a British statutory advisory non-departmental public body, which was established under the Misuse of Drugs Act 1971. Mandate Its terms of reference, according to the Act, are as follows: ...

(ACMD) recommended that AL-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use. The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.

United States

AL-LAD is a Controlled Substance at the federal level in the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

, AL-LAD could be legally considered an

analog Analog or analogue may refer to: Computing and electronics * Analog signal, in which information is encoded in a continuous variable ** Analog device, an apparatus that operates on analog signals *** Analog electronics, circuits which use analog ...

of the Schedule I drug

LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...

, therefore, sales, possession or consumption for recreational not medical nor scientific use could be prosecuted under the

Federal Analogue Act The Federal Analogue Act, , is a section of the United States Controlled Substances Act passed in 1986 which allows any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were listed ...

References

External links

AL-LAD - Isomer Design

AL-LAD - PsychonautWiki

AL-LAD Experience Reports - Erowid

The Big & Dandy AL-LAD Thread - Bluelight

AL-LAD - UK Chemical Research

AL-LAD - TiHKAL - Erowid

AL-LAD - TiHKAL - Isomer Design

AL-LAD: Is This “Friendly” Acid Alternative Legit? - Tripsitter
{{Ergolines 5-HT2A agonists Allylamines Designer drugs Psychedelic lysergamides Serotonin receptor agonists