ADX-71441 is a GABA_B receptor

positive allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli. Some of them, like benzodiazepines or alcohol, function as psychoactive drugs. The site that ...

currently being investigated as a potential treatment for anxiety, epilepsy, pain and other conditions.

Therapeutic potential

Addiction

ADX-71441 has been shown to reduce

alcohol consumption Drinks containing alcohol (drug), alcohol are typically divided into three classes—beers, wines, and Distilled beverage, spirits—with alcohol content typically between 3% and 50%. Drinks with less than 0.5% are sometimes considered Non-al ...

. This result was observed in both alcohol dependent and non-dependent animals. There were also trials about

nicotine addiction Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and '' Duboisia hopwoodii'') and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used fo ...

, which showed positive results: ADX-71441 was able to decrease some

withdrawal symptoms Withdrawal means "an act of taking out" and may refer to: * Anchoresis (withdrawal from the world for religious or ethical reasons) * ''Coitus interruptus'' (the withdrawal method) * Drug withdrawal * Social withdrawal * Taking of money from a ban ...

of nicotine withdrawal.

Anxiety

This compound has also been shown to reduce anxiety in people with

PTSD Post-traumatic stress disorder (PTSD) is a mental disorder that develops from experiencing a traumatic event, such as sexual assault, domestic violence, child abuse, warfare and its associated traumas, natural disaster, traffic collision, ...

Pain

Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.

Tolerance

ADX-71441 has been shown to have less tolerance and side effects than direct GABA_B agonists, such as

baclofen Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life, and ...

References

{{GABA receptor modulators GABA receptor ligands Fluoroarenes Acetamides Methoxy compounds Triazines Chloroarenes Ureas