In
biochemistry, a dual-specificity kinase () is a
kinase
In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule don ...
that can act as both
tyrosine kinase and
serine/threonine kinase.
MEKs, involved in
MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:
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ADK1 (Arabidopsis dual specificity kinase 1)
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CLK1,
CLK2
Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the ''CLK2'' gene.
Function
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and p ...
,
CLK3,
CLK4
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DSTYK
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DYRK1A,
DYRK1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the ''DYRK1B'' gene.
Function
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization s ...
,
DYRK2,
DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the ''DYRK3'' gene.
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on ser ...
,
DYRK4
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Mps1p
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TESK1
Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the ''TESK1'' gene.
Function
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal ...
,
TESK2
Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the ''TESK2'' gene.
Function
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structur ...
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TTK
The
systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).
References
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EC 2.7.12
Enzymes of unknown structure
{{2.7-enzyme-stub