ADBICA (also known as ADB-PICA) is a
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
identified in
synthetic cannabis blends in Japan in 2013. ADBICA had not previously been reported in the scientific literature prior to its sale as a component of synthetic cannabis blends. ADBICA features a carboxamide group at the 3-indole position, like
SDB-001 and
STS-135
STS-135 ( ISS assembly flight ULF7) was the 135th and final mission of the American Space Shuttle program. It used the orbiter '' Atlantis'' and hardware originally processed for the STS-335 contingency mission, which was not flown. STS-135 ...
. The stereochemistry of the tert-butyl side-chain in the product is unresolved, though in a large series of indazole derivatives structurally similar to ADBICA that are disclosed in Pfizer patent WO 2009/106980, activity resides exclusively in the (S) enantiomers. ADBICA is a potent
agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
of the
CB1 receptor and
CB2 receptor with an EC
50 value of 0.69 nM and 1.8 nM respectively.
Legal Status
As of October 2015 ADBICA is a controlled substance in China.
See also
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5F-AB-PINACA
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5F-ADB
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5F-ADBICA
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5F-AMB
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5F-APINACA
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AB-FUBINACA
AB-FUBINACA ( AMB-FUBINACA) is a psychoactive drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. I ...
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AB-CHFUPYCA
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AB-CHMINACA
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AB-PINACA
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ADB-CHMINACA
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ADB-FUBINACA
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ADB-PINACA
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ADB-P7AICA
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APICA
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APINACA
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MDMB-CHMICA
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PF-03550096
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STS-135
STS-135 ( ISS assembly flight ULF7) was the 135th and final mission of the American Space Shuttle program. It used the orbiter '' Atlantis'' and hardware originally processed for the STS-335 contingency mission, which was not flown. STS-135 ...
*
PX-3
References
Cannabinoids
Designer drugs
Indolecarboxamides
Tert-butyl compounds
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