ACV synthetase (ACVS,
L-δ-(α-aminoadipoyl)-
L-cysteinyl-
D-valine synthetase, ''N''-(5-amino-5-carboxypentanoyl)-
L-cysteinyl-
D-valine synthase, ) is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that
catalyzes the
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
:3 ATP +
L-2-aminohexanedioate +
L-cysteine +
L-valine + H
2O
3 AMP + 3 PP
i + ''N''-
small>L-5-amino-5-carboxypentanoylL-cysteinyl-
D-valine
The five
substrates of this enzyme are
ATP,
L-2-aminohexanedioate,
L-
cysteine
Cysteine (; symbol Cys or C) is a semiessential proteinogenic amino acid with the chemical formula, formula . The thiol side chain in cysteine enables the formation of Disulfide, disulfide bonds, and often participates in enzymatic reactions as ...
,
L-
valine, and
H2O, whereas its three
products are
AMP,
diphosphate, and ''N''-
small>L-5-amino-5-carboxypentanoylL-cysteinyl-
D-valine.
ACVS is an example of a
nonribosomal peptide synthetase (NRPS). It participates in
penicillin
Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...
and
cephalosporin
The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus '' Acremonium'', which was previously known as ''Cephalosporium''.
Together with cephamycins, they constitute a subgroup of β-lactam antibio ...
biosyntheses.
References
*
*
EC 6.3.2
Enzymes of unknown structure
{{6.3-enzyme-stub