Acyl-CoA dehydrogenase family, member 10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ACAD10
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Structure
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Clinical significance
In
Pima people
The Pima (or Akimel O'odham, also spelled Akimel Oʼotham, "River People," formerly known as ''Pima'') are a group of Native Americans in the United States, Native Americans living in an area consisting of what is now central and southern Arizo ...
, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two
single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and
American Indians.
Interactions
Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with
P2RY8
P2Y purinoceptor 8 is a protein that in humans is encoded by the ''P2RY8'' gene.
Function
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleot ...
,
NDUFA10
NADH dehydrogenase biquinone1 alpha subcomplex subunit 10 is an enzyme that in humans is encoded by the NDUFA10 gene. The NDUFA10 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is ...
,
NTRK3,
SLC2A12,
LPAR4,
PTH1R,
COLEC10,
APP
App, Apps or APP may refer to:
Computing
* Application software
* Mobile app, software designed to run on smartphones and other mobile devices
* Web application or web app, software designed to run inside a web browser
* Adjusted Peak Performan ...
,
MAS1,
CD79A
Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.
The CD79a protein together with the related C ...
,
BSG, and
Ubiquitin C
Polyubiquitin-C is a protein encoded by the ''UBC'' gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A.
''UBC'' gene is one of the two stress-regulated polyubiquitin genes (''UBB'' and ''UBC'' ...
.
References
External links
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Further reading
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Proteins
Genes on human chromosome 12
{{gene-12-stub