ABI3
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ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ABI3''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a
homeobox A homeobox is a Nucleic acid sequence, DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. Mutations in a homeobox may change large-scale anatomical features of ...
homology
domain A domain is a geographic area controlled by a single person or organization. Domain may also refer to: Law and human geography * Demesne, in English common law and other Medieval European contexts, lands directly managed by their holder rather ...
,
proline Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group but is rather a secondary amine. The secondary amine nitrogen is in the p ...
rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic
metastasis Metastasis is a pathogenic agent's spreading from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, ...
of tumor cells as well as
cell migration Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryogenesis, embryonic development, wound healing and immune system, immune responses all require the orchestrated movemen ...
. This may be accomplished through interaction with
p21-activated kinases p21 activated kinases (PAKs) are members of a family of enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), subst ...
.


See also

* ABI1 *
ABI2 Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ''ABI2'' gene. Interactions ABI2 has been shown to interact with ABL1, ADAM19, and TRIM32 Tripartite motif-containing protein 32 is a ...
* ABI3BP


References


External links

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Further reading

* * * * * * * * * {{gene-17-stub