ATP-binding cassette sub-family F member 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''ABCF2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a member of the superfamily of
ATP-binding cassette
The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transpo ...
(ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily.
Alternative splicing of this gene results in multiple transcript variants.
ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (
CLCN3
H+/Cl− exchange transporter 3 is a protein that in humans is encoded by the ''CLCN3'' gene.
Interactions
CLCN3 has been shown to interact with PDZK1.
See also
* Chloride channel
Chloride channels are a superfamily of poorly understood i ...
).
See also
*
ATP-binding cassette transporter
The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transpo ...
References
Further reading
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External links
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ATP-binding cassette transporters
Genes on human chromosome 7
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