8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ
9-THC) is an
active metabolite
An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical. Active metabolites may produce therapeutic effects, as well as harmful effects. ...
of
THC, the main active component of
cannabis
''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...
. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than
11-hydroxy-THC, making 8,11-dihydroxy-THC potentially useful for
drug testing
A drug test (also often toxicology screen or tox screen) is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs o ...
to distinguish between recent cannabis use and use longer in the past.
See also
*
3'-Hydroxy-THC
3'-Hydroxy-THC (3'-OH-Δ9-THC) is a minor active metabolite of THC, the main psychoactive component of cannabis. It is one of a number of metabolites of THC hydroxylated on the pentyl side chain, but while the other side-chain hydroxyl isomers a ...
*
7-Hydroxycannabidiol
7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. While methods have been developed for its synthetic production, and measurement of levels in the b ...
*
11-Hydroxy-Delta-8-THC
*
11-Nor-9-carboxy-THC
11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC) which is formed in the body after cannabis is co ...
*
Cannabitriol
Cannabitriol (CBT) is a phytocannabinoid first isolated in 1966, an oxidation product of tetrahydrocannabinol (THC) which has been identified both as a trace component of cannabis and as a metabolite in cannabis users. Its pharmacology has been ...
*
Cannabiripsol
Cannabiripsol is a minor phytocannabinoid with a hexahydrocannabinol backbone, found in trace amounts in the cannabis plant. While it lacks activity at cannabinoid receptors, its activity at other targets has not been studied.
See also
* 8- ...
References
Benzochromenes
Cannabinoids
Recreational drug metabolites
{{cannabinoid-stub