7-F-5-MeO-MET (5-MeO-7-F-MET, 5-Methoxy-7-fluoro-''N''-methyl-''N''-ethyltryptamine) is a
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...
derivative which acts as a
serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...
agonist selective for the 5-HT
2 subtypes, with a
pEC50 of 8.71 at
5-HT2A, vs 8.25 at
5-HT2B and 7.69 at
5-HT2C. In animal tests it produced the most potent
head-twitch response
The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...
of a range of related fluorinated tryptamine derivatives tested, though still with slightly lower potency than
psilocybin
Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
.
[ Retrieved 2025-05-14]
See also
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7-Chloro-AMT
7-Chloro-α-methyltryptamine (7-Cl-AMT) is a tryptamine derivative with stimulant effects, invented in the 1960s. It is a weak monoamine oxidase inhibitor but its pharmacology has not otherwise been studied by modern techniques, though several cl ...
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5-Fluoro-MET
Bretisilocin, also known by its developmental code name GM-2505 and as 5-fluoro-''N''-methyl-''N''-ethyltryptamine (5F-MET or 5-fluoro-MET), is a serotonergic psychedelic of the tryptamine family which is under development for the treatment of ...
*
4-Fluoro-5-methoxy-DMT
4-Fluoro-5-Methoxy-''N'',''N''-dimethyltryptamine (4-F-5-MeO-DMT) was first described by David E. Nichols team in 2000. It is a potent 5-HT1A agonist. Substitution with the 4-fluorine markedly increased 5-HT1A selectivity over 5-HT2A/2C receptors ...
*
5-MeO-MET
5-MeO-MET, also known as 5-methoxy-''N''-methyl-''N''-ethyltryptamine, is a serotonin receptor modulator, putative serotonergic psychedelic, and relatively rare designer drug of the tryptamine family related to psychedelic drugs like methylethylt ...
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Methylethyltryptamine
Methylethyltryptamine (MET), also known as ''N''-methyl-''N''-ethyltryptamine (''N'',''N''-MET), is a serotonergic psychedelic of the tryptamine family. It is closely related to dimethyltryptamine (DMT) and to diethyltryptamine (DET). The drug ...
(MET)
*
5-Methoxy-7,N,N-trimethyltryptamine
5-Methoxy-7,''N'',''N''-trimethyltryptamine (5-MeO-7,''N'',''N''-TMT, 5-MeO-7-TMT), is a tryptamine derivative which acts as a partial agonist at the 5-HT2 serotonin receptors, with an EC50 of 63.9 nM and an efficacy of 66.2% at 5-HT2A (vs 5-H ...
*
O-4310
O-4310, also known as 1-isopropyl-6-fluoropsilocin, is a serotonin receptor agonist of the tryptamine family. It is the 1-isopropylated and 6- flourinated derivative of the serotonergic psychedelic psilocin.
Pharmacology
The drug is said to be ...
References
{{Tryptamines
Designer drugs
N,N-Dialkyltryptamines
Fluoroarenes
5-Methoxytryptamines
Psychedelic tryptamines
Serotonin receptor agonists