6-Phosphogluconic acid (6-phosphogluconate) is an intermediate in the
pentose phosphate pathway
The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt and the HMP Shunt) is a metabolic pathway parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-p ...
and the
Entner–Doudoroff pathway
The Entner–Doudoroff pathway (ED Pathway) is a metabolic pathway that is most notable in Gram-negative bacteria, certain Gram-positive bacteria and archaea. Glucose is the substrate in the ED pathway and through a series of enzyme assisted che ...
.
It is formed by
6-phosphogluconolactonase
6-Phosphogluconolactonase (EC 3.1.1.31, 6PGL, PGLS, systematic name 6-phospho-D-glucono-1,5-lactone lactonohydrolase) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid ...
, and acted upon by
phosphogluconate dehydrogenase to produce
ribulose 5-phosphate
Ribulose 5-phosphate is one of the end-products of the pentose phosphate pathway. It is also an intermediate in the Calvin cycle.
It is formed by phosphogluconate dehydrogenase, and it can be acted upon by phosphopentose isomerase and phosphope ...
. It may also be acted upon by 6-
phosphogluconate dehydratase
The enzyme phosphogluconate dehydratase () catalyzes the chemical reaction
:6-phospho-D-gluconate \rightleftharpoons 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which ...
to produce 2-keto-3-deoxy-6-phosphogluconate.
Organophosphates
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