5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in

e-cigarette An electronic cigarette (e-cigarette), or vape, is a device that simulates smoking. It consists of an atomizer, a power source such as a battery, and a container such as a cartridge or tank. Instead of smoke, the user inhales vapor. As such ...

form as C-Liquid) is an indazole-3-carboxamide based

synthetic cannabinoid Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that Binding affinity, bind to the same receptors to which cannabinoids (Tetrahydrocannabinol, THC, Cannabidiol, CBD and many others) in cannabis plants attach. Th ...

. 5F-CUMYL-PINACA acts as a potent

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

for the

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cann ...

s, with the original patent claiming approximately 4x selectivity for CB₁, having an EC₅₀ of <0.1 nM for human CB₁ receptors and 0.37 nM for human CB₂ receptors. In more recent assays using different techniques, 5F-CUMYL-PINACA was variously found to have an EC₅₀ of 0.43 nM at CB₁ and 11.3 nM at CB₂, suggesting a somewhat higher CB₁ selectivity of 26 times, or alternatively 15.1 nM at CB₁ and 34.8 nM at CB₂ with only 2.3 times selectivity, however these figures cannot be directly compared due to the different assay techniques used in each case.

Legal status

In the United States, 5F-CUMYL-PINACA was temporarily emergency scheduled by the DEA in 2019. and made a permanent

Schedule I Controlled Substance The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United State ...

on April 7, 2022. Sweden's public health agency suggested classifying 5F-CUMYL-PINACA as a hazardous substance on November 10, 2014.

References

{{Cannabinoidergics Cannabinoids Designer drugs Indazolecarboxamides Organofluorides

Legal status

See also

References