5-OH-DPAT is a synthetic compound that acts as a
dopamine receptor agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
with selectivity for the
D2 receptor and
D3 receptor subtypes.
Only the (''S'')-enantiomer is active as an agonist, with the (''R'')-enantiomer being a weak antagonist at D
2 receptors.
C-5-OH-DPAT is used as an agonist radioligand for mapping the distribution and function of D
2 and D
3 receptors in the brain,
and the drug is also being studied in the treatment of
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
.
See also
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7-OH-DPAT
7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype, and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT. 7-OH-DPAT is self-administer ...
*
8-OH-DPAT
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor, 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonis ...
References
2-Aminotetralins
Dipropylamino compounds
Hydroxyarenes
Dopamine agonists
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