5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a
5-HT1 receptor protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
and also denotes the human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
encoding it.
Agonists
* 5-''n''-Butyryloxy-DMT: >60-fold selectivity versus 5-HT
1E receptor
*
BRL-54443
BRL-54443 is a drug which acts as a selective agonist for the 5-HT1E and 5-HT1F serotonin receptor subtypes.
See also
* CP-94253
* RS134-49
* RU-24969
* Sertindole
* SN-22
SN-22 is a chemical compound which acts as a moderately select ...
- mixed 5-HT
1E/1F agonist
*
Eletriptan
Eletriptan, sold under the brand name Relpax and used in the form of eletriptan hydrobromide, is a second-generation triptan medication intended for treatment of migraine headaches. It is used as an abortive medication, blocking a migraine at ...
- mixed 5-HT
1B/1D/1E/1F/2B/7 agonist
*
LY-334,370
LY-334370 is a selective 5-HT1F receptor agonist which was under development by Eli Lilly and Company for the treatment of migraine headaches. The drug showed efficacy in a phase II clinical trial but further development was halted due to toxic ...
- as well as related
benzamide
Benzamide is an organic compound with the chemical formula of C7H7NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals. It is slightly ...
s
*
LY-344,864 (N-
3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl4-fluorobenzamide)
*
Naratriptan
Naratriptan (trade names include Amerge) is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. It is a selective 5-HT1 receptor subtype agonist.
It was patented in 1987 and approved for medical use ...
- mixed 5-HT
1B/1D/1F agonist
*
Lasmiditan
Lasmiditan, sold under the brand name Reyvow, is a medication used for the acute (active but short-term) treatment of migraine with or without aura (a sensory phenomenon or visual disturbance) in adults. It is not useful for prevention. It is ...
- selective 5-HT
1F agonist, a first-in-class
ditan
Ditans are a class of abortive medication for the treatment of migraines. The first ditan, Eli Lilly's lasmiditan, was approved by the FDA in 2019.
Ditans selectively bind to the 5-HT1F receptor subtype. A number of triptans have been shown t ...
molecule
Antagonists
MLS000756415
PubChem: MLS000756415
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See also
* 5-HT1 receptor
* 5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the Central nervous system, central and peripheral nervous systems ...
References
Further reading
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External links
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Serotonin receptors
{{transmembranereceptor-stub