2,5-Dimethoxy-4-ethylthio-α-ethylphenethylamine (4C-T-2) is a
synthetic drug Synthetic drugs refer to substances that are artificially modified from naturally-occurring drugs and are capable of exhibiting both therapeutic and psychoactive effects.
In the medical setting, synthetic drugs possess psychotropic effects which ca ...
of the
phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace am ...
chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classifica ...
. It is the
α-
ethylated analogue of
2C-T-2
2C-T-2 is a psychedelic and entactogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin, and rated by him as one of the "magical half-dozen" most important psychedelic phenethylamine compounds. The drug ...
.
Pharmacology
Binding profile
4C-T-2 has
affinity (K
i) for the
5-HT1A (5,339 nM),
5-HT1E (9,879 nM),
5-HT2A (274.1 nM),
5-HT2B (58.1 nM),
5-HT2C (468.6 nM),
5-HT5A (1,587 nM),
5-HT7 (3,829),
D3 (1,273 nM),
β2-adrenergic (124.9 nM),
I1 (946.5 nM), and
σ1 (514 nM)
receptors.
The
activity of 4C-T-2 at these sites has not been assayed, with the exception of the 5-HT
2A and 5-HT
2C receptors where it acts as a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonist ...
.
See also
*
2C-T-2
2C-T-2 is a psychedelic and entactogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin, and rated by him as one of the "magical half-dozen" most important psychedelic phenethylamine compounds. The drug ...
*
4C-B
4C-B (also known as 4C-DOB or DOB-B) is a lesser-known psychedelic drug which is related to 2C-B and DOB. It is a reasonably potent 5-HT2A receptor partial agonist with a Ki of 7.6nM, but has relatively low efficacy (15% relative to 5-HT). It is ...
*
Aleph-7
*
Ariadne
Ariadne (; grc-gre, Ἀριάδνη; la, Ariadne) was a Cretan princess in Greek mythology. She was mostly associated with mazes and labyrinths because of her involvement in the myths of the Minotaur and Theseus. She is best known for havin ...
References
Phenethylamines
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