4-Pyridylnicotinamide (4-PNA), also known as ''N''-(pyridin-4-yl)nicotinamide, is a kinked dipodal dipyridine which was originally developed for use in chemotherapy.
As in its
isomer
In chemistry, isomers are molecules or polyatomic ions with identical molecular formulae – that is, same number of atoms of each element – but distinct arrangements of atoms in space. Isomerism is existence or possibility of isomers.
...
3-pyridylnicotinamide
The organic compound 3-pyridylnicotinamide (3-pna), also known as ''N''-(pyridin-3-yl)nicotinamide, is a kinked dipodal dipyridine that is synthesized through the reaction of nicotinoyl chloride and 3-aminopyridine. The nitrogen atoms on its pyr ...
, the nitrogen atoms on its pyridine rings can donate their
electron lone pairs to metal cations, allowing it to bridge metal centers and act as a
bidentate ligand
In coordination chemistry, a ligand is an ion or molecule ( functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's ele ...
in
coordination polymers.
It is synthesized through the reaction of nicotinoyl chloride and
4-aminopyridine.
References
Chelating agents
Nicotinamides
{{organic-compound-stub