In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a 4-chlorobenzoate dehalogenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:4-chlorobenzoate + H
2O
4-hydroxybenzoate + chloride
Thus, the two
substrates of this enzyme are
4-chlorobenzoate and
H2O, whereas its two
products are
4-hydroxybenzoate
4-Hydroxybenzoic acid, also known as ''p''-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar ...
and
chloride.
This enzyme belongs to the family of
hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The
systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with
PDB accession codes , , and .
References
*
*
EC 3.8.1
Enzymes of known structure
{{hydrolase-stub