3-Isopropylmalate dehydrogenase () is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that is a part of the
isopropylmalate dehydrogenase family, which
catalyzes
Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...
the
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
s:
:
(2R,3S)-3-isopropylmalate +
NAD+ 4-methyl-2-oxopentanoate +
CO2 +
NADH
Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an ade ...
:(2R,3S)-3-isopropylmalate + NAD
+ (2S)-2-isopropyl-3-oxosuccinate + H
+ + NADH
:(2S)-2-isopropyl-3-oxosuccinate + H
+ 4-methyl-2-oxopentanoate + CO
2
References
EC 1.1.1
NADPH-dependent enzymes
Enzymes of known structure
{{1.1.1-enzyme-stub