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3-hexulose-6-phosphate synthase (, ''D-arabino-3-hexulose 6-phosphate formaldehyde-lyase'', ''3-hexulosephosphate synthase'', ''3-hexulose phosphate synthase'', ''HPS'') is an
enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...
''D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)''. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...
: D-arabino-hex-3-ulose 6-phosphate \rightleftharpoons D-ribulose 5-phosphate +
formaldehyde Formaldehyde ( , ) ( systematic name methanal) is a naturally occurring organic compound with the formula and structure . The pure compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde (refer to section ...
This enzyme requires Mg2+ or Mn2+ for maximal activity.


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* {{Portal bar, Biology, border=no EC 4.1.2